I have fibromyalgia. I started taking 5-HTP on 1/31/09. It has made a significant improvement in the quality of my life. I bought SAMe, too. I haven't started taking it yet. I am 60yrs old. I weigh 92lbs, 4'10" tall. I take 5-HTP 3/day-6hrs apart,on an empty stomach. I am completely dependent on my daughter-no bank account, no health insurance. I haven't been able to see a Dr since 2006-so no meds. The only thing I take is tylenol, motrin, pepcid, and OTC allergy pills. (I do take vitamins & minerals) I haven't started taking the SAMe because I haven't been able to find out if it is safe to take both 5-HTP &SAMe. Also since both have to be taken on an empty stomach; I have to take both at the exact same time. (I have IBS- I can't have " " " for more than 12 hrs/day:an hour before & after). I have hypoglycemia-so even the 2 hrs make me dizzy. So back to my ?-can I take the SAMe, also? THANK YOU, IN ADVANCE Forgot-I take 100mg. 3/day. The SAMe is 200mg-suggested dosage is 400mg 3/day.